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. 1975 Nov 15;31(11):1315-7.
doi: 10.1007/BF01945801.

Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin

G Jones, J B Greig

Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin

G Jones et al. Experientia. .

Abstract

In C57BL/6 mice a single oral dose of 2,3,7,8-tetrachlorodibenzodioxin (LD50 126 mug/kg) results in loss of body weight and death with an enlarged fatty liver after ca. 21 days. A progressive necrotic centrilobular liver lesion is also seen.

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