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. 2002;4(1):E4.
doi: 10.1208/ps040104.

Protein binding predictions in infants

Patrick J McNamara  1 , Jane Alcorn
Affiliations

Protein binding predictions in infants

Patrick J McNamara et al. AAPS PharmSci. 2002.

Abstract

Plasma binding protein levels are lower in the newborn than in the adult and gradually increase with age. At birth, human serum albumin (HSA) concentrations are close to adult levels (75%-80%), while alpha 1-acid glycoprotein (AAG) is initially half the adult concentration. As a result, the extent of drug binding to HSA is closer to that of the adult than are those drugs bound largely to AAG. A model that incorporates the fraction unbound in adults and the ratio of the binding protein concentration between infants and adults successfully predicted the fraction unbound in infants and children.

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References

    1. Alcorn J, McNamara PJ. The ontogeny of hepatic and renal systemic clearance pathways in infants: a review (Part I). Clin Pharmacokinet. In press. - PubMed
    1. Alcorn J, McNamara PJ. The ontogeny of hepatic and renal systemic clearance pathways in infants: model predictions (Part II). Clin Pharmacokinet. In press. - PubMed
    1. Curry S, Brick P, Franks NP. Fatty acid binding to human serum albumin: new insights from crystallographic studies. Biochim Biophys Acta. 1999;1441(2–3):131–140. - PubMed
    1. Fournier T, Medjoubi NN, Porquet D. Alpha 1-acid glycoprotein. Biochim Biophys Acta. 2000;1482(1–2):157–171. - PubMed
    1. Kremer JM, Wilting J, Janssen LH. Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev. 1988;40(1):1–47. - PubMed

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