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Review
. 2002 May;9(5):931-43.
doi: 10.1016/s1097-2765(02)00540-3.

The anaphase-promoting complex: proteolysis in mitosis and beyond

Jan-Michael Peters  1
Affiliations
Free article
Review

The anaphase-promoting complex: proteolysis in mitosis and beyond

Jan-Michael Peters. Mol Cell. 2002 May.
Free article

Abstract

Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.

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