Review
doi: 10.2174/0929867023369998.
Bisphosphonate prodrugs
Affiliations
- PMID: 12052172
- DOI: 10.2174/0929867023369998
Item in Clipboard
Review
Bisphosphonate prodrugs
Curr Med Chem.
2002 Jun.
Abstract
Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).
Similar articles
-
A peptide prodrug approach for improving bisphosphonate oral absorption.J Med Chem. 2000 Oct 5;43(20):3641-52. doi: 10.1021/jm980645y. J Med Chem. 2000. PMID: 11020278
-
Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid.J Med Chem. 1999 Dec 2;42(24):5053-8. doi: 10.1021/jm991109o. J Med Chem. 1999. PMID: 10585214
-
Bisphosphonate prodrugs: synthesis and in vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate.Eur J Pharm Sci. 2000 Aug;11(2):173-80. doi: 10.1016/s0928-0987(00)00099-3. Eur J Pharm Sci. 2000. PMID: 10915965
-
Bisphosphonate therapy.Am J Med Sci. 1997 Jan;313(1):17-22. doi: 10.1097/00000441-199701000-00004. Am J Med Sci. 1997. PMID: 9001162 Review.
-
Administration routes and delivery systems of bisphosphonates for the treatment of bone resorption.Adv Drug Deliv Rev. 2000 Aug 31;42(3):175-95. doi: 10.1016/s0169-409x(00)00061-2. Adv Drug Deliv Rev. 2000. PMID: 10963835 Review.
Cited by
-
Design, Synthesis, Pharmacokinetics, and Biodistribution of a Series of Bone-Targeting EP4 Receptor Agonist Prodrugs for Treatment of Osteoporosis and Other Bone Conditions.ACS Pharmacol Transl Sci. 2021 Mar 10;4(2):908-925. doi: 10.1021/acsptsci.1c00027. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2021. PMID: 33860210 Free PMC article.
-
Structural requirements for bisphosphonate binding on hydroxyapatite: NMR study of bisphosphonate partial esters.ACS Med Chem Lett. 2015 Feb 21;6(4):397-401. doi: 10.1021/ml5004603. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893039 Free PMC article.
-
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use.Bone. 2022 Mar;156:116289. doi: 10.1016/j.bone.2021.116289. Epub 2021 Dec 8. Bone. 2022. PMID: 34896359 Free PMC article.
-
Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells.J Med Chem. 2011 Oct 13;54(19):6647-56. doi: 10.1021/jm200521a. Epub 2011 Sep 9. J Med Chem. 2011. PMID: 21863853 Free PMC article.
-
Drug-Eluting Biodegradable Implants for the Sustained Release of Bisphosphonates.Polymers (Basel). 2020 Dec 7;12(12):2930. doi: 10.3390/polym12122930. Polymers (Basel). 2020. PMID: 33297466 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
