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Comparative Study
. 2002 Jun;59(6):972-6.
doi: 10.1001/archneur.59.6.972.

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease

Domenico Praticò  1 , Christopher M Clark, Feyan Liun, Joshua Rokach, Virginia Y-M Lee, John Q Trojanowski
Affiliations
Comparative Study

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease

Domenico Praticò et al. Arch Neurol. 2002 Jun.

Erratum in

  • Arch Neurol 2002 Sep;59(9):1475

Abstract

Background: The isoprostane 8,12-iso-iPF(2alpha)-VI, a specific marker of in vivo lipid peroxidation, is increased in Alzheimer disease (AD). The pathological changes associated with AD have a long silent phase before the appearance of clinical symptoms. Several studies have shown that AD is preceded by a prodromal phase characterized by mild cognitive impairment (MCI).

Objective: To investigate levels of this biomarker in subjects with MCI.

Design and main outcome measures: Using gas chromatography-mass spectrometry analysis, we measured 8,12-iso-iPF(2alpha)-VI levels in urine, plasma, and cerebrospinal fluid of patients with AD, subjects with MCI, and cognitively normal elderly subjects.

Setting and patients: Subjects attending the Memory Disorders Clinic.

Results: We found significantly higher 8,12-iso-iPF(2alpha)-VI levels in cerebrospinal fluid, plasma, and urine of subjects with MCI compared with cognitively normal elderly subjects.

Conclusions: These results imply that individuals with MCI have increased brain oxidative damage before the onset of symptomatic dementia. Measurement of this isoprostane may identify a subgroup of patients with MCI with increased lipid peroxidation who are at increased risk to progress to symptomatic AD.

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