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Review
. 2002 Jun 11;99(12):7811-3.
doi: 10.1073/pnas.132280299.

Ganglioside rafts as MAG receptors that mediate blockade of axon growth

Lisa McKerracher  1
Affiliations
Review

Ganglioside rafts as MAG receptors that mediate blockade of axon growth

Lisa McKerracher. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Model showing MAG activation of Rho by binding gangliosides in membrane rafts. MAG expressed on the surface of oligodendrocytes interacts with gangliosides GD1a or GT1b present in growth cone membrane microdomains (light blue). Rho associates with ganglioside rafts on the cytoplasmic side. Signaling from activated Rho through Rho kinase provokes growth cone collapse and prevents axon elongation. Phosphorylation of Rho by protein kinase A causes Rho to dissociate from the membrane (26), and blocks growth cone collapse.
See this image and copyright information in PMC

Comment on

References

    1. Schwab M E, Kapfhammer J P, Bandtlow C E. Annu Rev Neurosci. 1993;16:565–595. - PubMed
    1. McKerracher L, David S, Jackson J L, Kottis V, Dunn R, Braun P E. Neuron. 1994;13:805–811. - PubMed
    1. Mukhopadhyay G, Doherty P, Walsh F S, Crocker P R, Filbin M T. Neuron. 1994;13:757–767. - PubMed
    1. Chen M S, Huber A B, van der Haar M, Frank M, Schnell L, Spillmann A A, Christ F, Schwab M E. Nature (London) 2000;403:434–438. - PubMed
    1. Prinjha R, Moore S E, Vinson M, Blake S, Morrow R, Christie G, Michalovich D, Simmons D L, Walsh F S. Nature (London) 2000;403:383–384. - PubMed