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Case Reports
. 2002 Jul 1;35(1):96-101.
doi: 10.1086/340859. Epub 2002 Jun 6.

Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis

Timo Hautala  1 , Tarja Sironen, Olli Vapalahti, Eija Pääkkö, Terttu Särkioja, Pasi I Salmela, Antti Vaheri, Alexander Plyusnin, Heikki Kauma
Affiliations
Case Reports

Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis

Timo Hautala et al. Clin Infect Dis. .

Abstract

We describe 3 cases of nephropathia epidemica (NE) that confirm that Puumala virus infection may cause hypophyseal injury. Autopsy revealed a hemorrhagic hypophysis positive for Puumala virus antigen in both neuroendocrine stromal and vascular endothelial cells in 1 patient, and 2 patients developed hypophyseal hemorrhage (diagnosed with magnetic resonance imaging) during or shortly after acute NE, both of whom developed panhypopituitarism.

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