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. 1975 Dec;41(06):1178-80.
doi: 10.1210/jcem-41-6-1178.

Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin

J E Gerich, E Tsalikian, M Lorenzi, V Schneider, N V Bohannon, G Gustafson, J H Karam

Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin

J E Gerich et al. J Clin Endocrinol Metab. 1975 Dec.

Abstract

Infusion of insulin (1 U/hr) for 14 hr suppressed basal glucagon levels and normalized previously excessive glucagon responses to arginine in juvenile-onset, insulin-dependent diabetic subjects, indicating that abnormal pancreatic alpha-cell function in human juvenile-onset diabetes mellitus may be a consequence of insulin lack.

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