Retinal waves: implications for synaptic learning rules during development

Abstract

Neural activity is often required for the final stages of synaptic refinement during brain development. It is thought that learning rules acting at the individual synapse level, which specify how pre- and postsynaptic activity lead to changes in synaptic efficacy, underlie such activity-dependent development. How such rules might function in vivo can be addressed in the retinogeniculate system because the input activity from the retina and its importance in development are both known. In fact, detailed studies of retinal waves have revealed their complex spatiotemporal properties, providing insights into the mechanisms that use such activity to guide development. First of all, the information useful for development is contained in the retinal waves and can be quantified, placing constraints on synaptic learning rules that use this information. Furthermore, knowing the distribution of activity over the entire set of inputs makes it possible to address a necessary component of developmental refinement: rules governing competition between synaptic inputs. In this way, the detailed knowledge of retinal input and lateral geniculate nucleus development provides a unique opportunity to relate the rules of synaptic plasticity directly to their role in development.