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Review
. 2002 May 31;109(5):541-4.
doi: 10.1016/s0092-8674(02)00765-1.

PI 3-kinases and PTEN: how opposites chemoattract

Frank I Comer  1 , Carole A Parent
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Free article
Review

PI 3-kinases and PTEN: how opposites chemoattract

Frank I Comer et al. Cell. .
Free article

Abstract

Phosphatidylinositol lipids, such as PI(4,5)P2 and PI(3,4,5)P3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.

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