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Review
. 2002 Jun;15(6):673-8.
doi: 10.1038/modpathol.3880585.

Primary peripheral PNET/Ewing's sarcoma of the dura: a clinicopathologic entity distinct from central PNET

Franceska Dedeurwaerdere  1 , Caterina Giannini, Raf Sciot, Brian P Rubin, Giorgio Perilongo, Laura Borghi, Maria Luisa Ballotta, Erwin Cornips, Anouk Demunter, Brigitte Maes, Angelo P Dei Tos
Affiliations
Review

Primary peripheral PNET/Ewing's sarcoma of the dura: a clinicopathologic entity distinct from central PNET

Franceska Dedeurwaerdere et al. Mod Pathol. 2002 Jun.

Abstract

We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.

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