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Review
. 2002 May;7(2):113-46.
doi: 10.1081/pdt-120003494.

Hydrolysis in pharmaceutical formulations

Kenneth C Waterman  1 , Roger C Adami, Karen M Alsante, Amy S Antipas, Dan R Arenson, Rebecca Carrier, Jinyang Hong, Margaret S Landis, Franco Lombardo, Jaymin C Shah, Evgenyi Shalaev, Scott W Smith, Hai Wang
Affiliations
Review

Hydrolysis in pharmaceutical formulations

Kenneth C Waterman et al. Pharm Dev Technol. 2002 May.

Abstract

This literature review presents hydrolysis of active pharmaceutical ingredients as well as the effects on dosage form stability due to hydrolysis of excipients. Mechanisms and measurement methods are discussed and recommendations for formulation stabilization are listed.

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