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Review
. 2001 Jul-Sep;5(3):254-66.
doi: 10.1111/j.1582-4934.2001.tb00159.x.

Apolipoprotein E: a major piece in the Alzheimer's disease puzzle

A Cedazo-Mínguez  1 , R F Cowburn
Affiliations
Review

Apolipoprotein E: a major piece in the Alzheimer's disease puzzle

A Cedazo-Mínguez et al. J Cell Mol Med. 2001 Jul-Sep.

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder with multiple etiologies. The presence of the E4 isoform of apolipoprotein E (apoE) has been shown to increase the risk and to decrease the age of onset for AD and is the major susceptibility factor known for the disease. ApoE4 has been shown to intensify all the biochemical disturbances characteristic of AD, including beta amyloid (Abeta) deposition, tangle formation, neuronal cell death, oxidative stress, synaptic plasticity and dysfunctions of lipid homeostasis and cholinergic signalling. In contrast, other apoE isoforms are protective. Here we review and discuss these major hypotheses of the apoE4-AD association.

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References

    1. Selkoe D.J., Alzheimer's Disease: Genes, Proteins and Therapy, Phys. Rev., 81: 741–766, 2001. - PubMed
    1. Kehoe P., Wavrant‐De Vrieze. F , Crook R., Wu W.S., Holmans P., Fenton I., Spurlock G., Norton N., Williams H., Williams N., Lovestone S., PerezTur J., Hutton M., Chartier‐Harlin M.C., Shears S., Roehl K., Booth J., Van Voorst W., Ramic D., Williams J., Goate A., Hardy J., Owen M.J., A full genome scan for late onset Alzheimer's disease, Hum. Mol. Genet., 8: 237–45, 1999. - PubMed
    1. Beffert U., Danik M., Krzykowski P., Ramassamy C., Berrada F., Poirier J., The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease, Brain Res. Rev., 27: 119–142, 1998. - PubMed
    1. Weisgraber K.H. and Mahley R.W., Human apolipoprotein E: the Alzheimer's Disease connection, FASEB J., 10: 1485–1494, 1996. - PubMed
    1. Baskin F., Smith G.M., Fosmire J.A., Rosenberg R.N., Altered apolipoprotein E secretion in cytokine treated human astrocyte cultures, J. Neurol. Sci., 148: 15–8, 1997. - PubMed

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