Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Jul;88(1):61-6.
doi: 10.1136/heart.88.1.61.

Infective endocarditis: determinants of long term outcome

R O M Netzer  1 , S C Altwegg, E Zollinger, M Täuber, T Carrel, C Seiler
Affiliations

Infective endocarditis: determinants of long term outcome

R O M Netzer et al. Heart. 2002 Jul.

Abstract

Objective: To evaluate predictors of long term prognosis in infective endocarditis.

Design: Retrospective cohort study.

Setting: Tertiary care centre.

Patients: 212 consecutive patients with infective endocarditis between 1980 and 1995

Main outcome measures: Overall and cardiac mortality; event-free survival; and the following events: recurrence, need for late valve surgery, bleeding and embolic complications, cerebral dysfunction, congestive heart failure.

Results: During a mean follow up period of 89 months (range 1-244 months), 56% of patients died. In 180 hospital survivors, overall and cardiac mortality amounted to 45% and 24%, respectively. By multivariate analysis, early surgical treatment, infection by streptococci, age < 55 years, absence of congestive heart failure, and > 6 symptoms or signs of endocarditis during active infection were predictive of improved overall long term survival. Independent determinants of event-free survival were infection by streptococci and age < 55 years. Event-free survival was 17% at the end of follow up both in medically-surgically treated patients and in medically treated patients.

Conclusions: Long term survival following infective endocarditis is 50% after 10 years and is predicted by early surgical treatment, age < 55 years, lack of congestive heart failure, and the initial presence of more symptoms of endocarditis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Overall survival in patients treated both medically and surgically (MST) versus those treated medically only (MT).
Figure 2
Figure 2
Cardiac mortality in the medically and surgically (MST) treated group versus those treated medically only (MT).
Figure 3
Figure 3
Overall survival of hospital survivors.
Figure 4
Figure 4
Overall survival in native valve endocarditis
See this image and copyright information in PMC

References

    1. Croft CH, Woodward W, Elliott A, et al. Analysis of surgical versus medical therapy in active complicated native valve infective endocarditis. Am J Cardiol 1983;51:1650–5. - PubMed
    1. Olaison L, Hogevik H, Myken P, et al. Early surgery in infective endocarditis. Q J Med 1996;89:267–78. - PubMed
    1. Richardson JV, Karp RB, Kirklin JW, et al. Treatment of infective endocarditis: a 10-year comparative analysis. Circulation 1978;58:589–97. - PubMed
    1. Nissen H, Nielsen PF, Frederiksen M, et al. Native valve infective endocarditis in the general population: a 10-year survey of the clinical picture during the 1980s. Eur Heart J 1992;13:872–7. - PubMed
    1. Watanakunakorn C, Burkert T. Infective endocarditis at a large community teaching hospital, 1980–1990: a review of 210 episodes. Medicine (Baltimore) 1993;72:90–102. - PubMed

MeSH terms