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. 2002 Jul;46(7):2254-6.
doi: 10.1128/AAC.46.7.2254-2256.2002.

Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1

Karidia Diallo  1 , Maureen Oliveira, Daniela Moisi, Bluma Brenner, Mark A Wainberg, Matthias Götte
Affiliations

Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1

Karidia Diallo et al. Antimicrob Agents Chemother. 2002 Jul.

Abstract

We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.

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