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Review
. 2002 Jun;109(12):1533-6.
doi: 10.1172/JCI15970.

TGF-beta antagonists: why suppress a tumor suppressor?

Rosemary J Akhurst  1
Affiliations
Review

TGF-beta antagonists: why suppress a tumor suppressor?

Rosemary J Akhurst. J Clin Invest. 2002 Jun.
No abstract available

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Figures

Figure 1
Figure 1
The TGF-β signaling pathway. TGF-βs bind and activate the TGF-β receptor complex, which transmits signal predominantly via activation and nuclear translocation of Smad proteins. However, several Smad-independent signaling pathways are also activated by this receptor complex, and the outcome of Smad signaling can be modified by interaction with other signaling pathways (1).
Figure 2
Figure 2
The balance between the autocrine homeostatic and tumor-progressing activities of TGF-β is perturbed by activation of oncogenic signaling pathways. As tumor progression proceeds, the homeostatic branch of TGF-β action becomes increasingly compromised, and tumors secrete more TGF-β1, thus exacerbating tumor progression.
See this image and copyright information in PMC

Comment on

References

    1. Derynck R, Akhurst RJ, Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat Genet. 2001;29:117–129. - PubMed
    1. Akhurst RJ, Derynck R. TGF-β signaling in cancer: a double-edged sword. Trends Cell Biol. 2001;11:S44–S51. - PubMed
    1. Wakefield LM, Roberts AB. TGF-β signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev. 2002;12:22–29. - PubMed
    1. Janda E, et al. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol. 2002;156:299–313. - PMC - PubMed
    1. Kakonen, S.M., et al. 2002. TGFβ stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. J. Biol. Chem. In press. - PubMed

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