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Review
. 2002 Apr;12(2):103-28.
doi: 10.1089/108729002760070849.

Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action

Muthiah Manoharan  1
Affiliations
Review

Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action

Muthiah Manoharan. Antisense Nucleic Acid Drug Dev. 2002 Apr.

Abstract

This review summarizes the effect of conjugating small molecules and large biomacromolecules to antisense oligonucleotides to improve their therapeutic potential. In many cases, favorable changes in pharmacokinetic and pharmacodynamic properties were observed. Opportunities exist to change the terminating mechanism of antisense action or to enhance the RNase H mode of action via conjugate formation.

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