[Ultrastructural and microbiological studies on the activity of azlocillin against Pseudomonas aeruginosa (author's transl)]

Abstract

To examine the effect of 6-[(R)-2-(2-oxo-imidazolidine-1-carboxamido)-2-phenyl-acetamido]-penicillanic acid sodium salt (azlocillin, Securopen) on the ultrastructure of Pseudomonas aeruginosa investigations were carried out by electron microscopy on thin sections and on negative-stained preparations. Depending on the concentration and the contact time of azlocillin the bacteria showed distinct alterations. The bacterial cells did not build septa and therefore only grew in length up to 100-fold that of untreated controls. The bacteria diameter remained unchanged. Survival curves showed that these bacterial filaments were unable to build colonies. They were irreversibly damaged.