Review
doi: 10.1016/s0968-0004(02)02086-8.
P450 BM3: the very model of a modern flavocytochrome
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- PMID: 12076537
- DOI: 10.1016/s0968-0004(02)02086-8
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Review
P450 BM3: the very model of a modern flavocytochrome
Trends Biochem Sci.
2002 May.
Abstract
Flavocytochrome P450 BM3 is a bacterial P450 system in which a fatty acid hydroxylase P450 is fused to a mammalian-like diflavin NADPH-P450 reductase in a single polypeptide. The enzyme is soluble (unlike mammalian P450 redox systems) and its fusion arrangement affords it the highest catalytic activity of any P450 mono-oxygenase. This article discusses the fundamental properties of P450 BM3 and how progress with this model P450 has affected our comprehension of P450 systems in general.
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