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Review
. 2002 May;27(5):250-7.
doi: 10.1016/s0968-0004(02)02086-8.

P450 BM3: the very model of a modern flavocytochrome

Andrew W Munro  1 , David G Leys, Kirsty J McLean, Ker R Marshall, Tobias W B Ost, Simon Daff, Caroline S Miles, Stephen K Chapman, Dominikus A Lysek, Christopher C Moser, Christopher C Page, P Leslie Dutton
Affiliations
Review

P450 BM3: the very model of a modern flavocytochrome

Andrew W Munro et al. Trends Biochem Sci. 2002 May.

Abstract

Flavocytochrome P450 BM3 is a bacterial P450 system in which a fatty acid hydroxylase P450 is fused to a mammalian-like diflavin NADPH-P450 reductase in a single polypeptide. The enzyme is soluble (unlike mammalian P450 redox systems) and its fusion arrangement affords it the highest catalytic activity of any P450 mono-oxygenase. This article discusses the fundamental properties of P450 BM3 and how progress with this model P450 has affected our comprehension of P450 systems in general.

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