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. 2002 Jul;51(1):65-9.
doi: 10.1136/gut.51.1.65.

Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer

V C Petersen  1 , K J Baxter, S B Love, N A Shepherd
Affiliations

Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer

V C Petersen et al. Gut. 2002 Jul.

Abstract

Background and aims: There is a need for objective easily determined pathological prognostic parameters in Dukes' B colon carcinoma to allow selection of such patients for further treatment as the role of adjuvant chemotherapy for these patients remains unclear. This study was initiated to assess the influence of pathological factors on prognosis in an unselected prospective series of Dukes' B colonic cancer.

Methods: The Gloucester Colorectal Cancer study, established in 1988, recruited more than 1000 cases. Meticulous pathological assessment of the 268 Dukes' B colonic cancer resections in this series included evaluation of all pathological factors that could influence staging and prognosis. All patients entered a comprehensive follow up system.

Results: Four pathologically determined factors--peritoneal involvement, venous spread (both submucosal and extramural), spread to involve a surgical margin, and perforation through the tumour-were independent prognostic factors in multivariate analysis. Combining these four factors into a simple cumulative scoring system generated clinically useful prognostic groups.

Conclusions: The cumulative prognostic index allows apportionment of patients with Dukes' B colon cancer into defined prognostic groups, which in turn could allow more objective selection of patients for adjuvant therapy, especially as part of clinical trials.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival graph of low and high risk Dukes' B colonic cancer.
See this image and copyright information in PMC

Comment in

  • A long hard look at Dukes' B.
    Williams GT. Williams GT. Gut. 2002 Jul;51(1):6-7. doi: 10.1136/gut.51.1.6. Gut. 2002. PMID: 12077080 Free PMC article. No abstract available.

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