Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes
- PMID: 1207711
Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes
Abstract
Sister chromatid exchange frequencies in human lymphocyte chromosomes are greatly increased by alkylating agents, but ionizing radiation has little if any such effect. Scoring these exchanges may provide a useful technique for exploring the mechanisms of chromosome breakage and repair.
Similar articles
-
Recombinational DNA repair and sister chromatid exchanges.Mutat Res. 1974 Aug;24(2):117-23. doi: 10.1016/0027-5107(74)90125-0. Mutat Res. 1974. PMID: 4854047 No abstract available.
-
Accurate detection of true incomplete exchanges in human lymphocytes exposed to neutron radiation using chromosome painting in combination with a telomeric PNA probe.Int J Radiat Biol. 2001 Dec;77(12):1175-83. doi: 10.1080/09553000110083951. Int J Radiat Biol. 2001. PMID: 11747542
-
Differential radiation effects in smokers--culture time dependence of the yield of gamma ray-induced chromosome damage in first division metaphases.Int J Radiat Biol. 2006 May;82(5):363-77. doi: 10.1080/09553000600774097. Int J Radiat Biol. 2006. PMID: 16782654
-
Factors that influence formation of sister chromatid exchanges in human blood lymphocytes.Crit Rev Toxicol. 1988;19(1):43-86. doi: 10.3109/10408448809040817. Crit Rev Toxicol. 1988. PMID: 3056658 Review.
-
Repair and chromosomal damage.Radiother Oncol. 2004 Sep;72(3):251-6. doi: 10.1016/j.radonc.2004.07.005. Radiother Oncol. 2004. PMID: 15450722 Review.
Cited by
-
Cyclophosphamide increases the frequency of sister chromatid exchange in direct preparations of human chorionic villi in the absence of supplementary enzymatic activation systems.J Med Genet. 1992 Feb;29(2):109-11. doi: 10.1136/jmg.29.2.109. J Med Genet. 1992. PMID: 1613760 Free PMC article.
-
Sister chromatid exchange in vivo, chromosomal characterization and NORs activity of leukemia cells during 5FU-treatments.Theor Appl Genet. 1987 Jun;74(2):247-52. doi: 10.1007/BF00289976. Theor Appl Genet. 1987. PMID: 24241572
-
Sensitivity of lymphocytes from patients with systemic lupus erythematosus to the induction of sister chromatid exchanges by alkylating agents and bromodeoxyuridine.Ann Rheum Dis. 1987 Feb;46(2):110-3. doi: 10.1136/ard.46.2.110. Ann Rheum Dis. 1987. PMID: 3827332 Free PMC article.
-
Sister chromatid exchanges in balanced translocation carriers and in patients with unbalanced karyotypes.Hum Genet. 1977 Jun 10;37(1):27-32. doi: 10.1007/BF00293768. Hum Genet. 1977. PMID: 881193
-
Sister chromatid exchange in lymphocytes from patients with malignant lymphoma.Hum Genet. 1978 Oct 31;44(2):137-44. doi: 10.1007/BF00295406. Hum Genet. 1978. PMID: 83281
MeSH terms
Substances
LinkOut - more resources
Full Text Sources