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. 1975 Dec 18;258(5536):577-80.
doi: 10.1038/258577a0.

Identification of two related pentapeptides from the brain with potent opiate agonist activity

J Hughes, T W Smith, H W Kosterlitz, L A Fothergill, B A Morgan, H R Morris

Identification of two related pentapeptides from the brain with potent opiate agonist activity

J Hughes et al. Nature. .

Abstract

Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.

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