doi: 10.1038/258577a0.
Identification of two related pentapeptides from the brain with potent opiate agonist activity
- PMID: 1207728
- DOI: 10.1038/258577a0
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Identification of two related pentapeptides from the brain with potent opiate agonist activity
Nature.
.
Abstract
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
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