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. 1998;16(2):101-4.

[Studies on cathepsins in Schistosoma japonicum]

[Article in Chinese]
Affiliations
  • PMID: 12078215

[Studies on cathepsins in Schistosoma japonicum]

[Article in Chinese]
Y Li et al. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1998.

Abstract

Aim: To identify the cathepsins in adult worms of Schistosoma japonicum and their proteolytic activities.

Methods: The vomitus from adult worms of S. japonicum was collected. The proteolytic activity of cathepsins in the vomitus was identified and measured using synthetic substrates with arginyl bonds.

Results: Specific synthetic subtracts Z-Arg-Arg-AMC (for cathepsin B) and Z-Phe-Arg-AMC (for cathepsin B and L) were degraded by the vomitus. An inhibitor, Z-Phe-PheCHN2 for cathepsin L, inhibited partially the activity of the vomitus to degrade Z-Phe-Arg-AMC. The optimal pH for cathepsin B/L is 5.0-5.5.

Conclusion: The vomitus of S. japonicum has cathepsin B- and L-like activity.

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