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. 2002 Jun 10;18(9):681-3.
doi: 10.1089/088922202760019400.

HIV-1 Subtype A, D, G, AG and unclassified sequences identified in South Africa

Helba Bredell  1 , Gillian Hunt, Alison Casteling, Tonie Cilliers, Celia Rademeyer, Mia Coetzer, Steven Miller, David Johnson, Caroline T Tiemessen, Desmond J Martin, Carolyn Williamson, Lynn Morris
Affiliations

HIV-1 Subtype A, D, G, AG and unclassified sequences identified in South Africa

Helba Bredell et al. AIDS Res Hum Retroviruses. .

Abstract

HIV-1 subtype C accounts for the vast majority of infections in South Africa. However, increasingly non-C subtypes are being detected. Here we report 10 viruses that contain sequences that group with subtypes A, D, and G as well as CRF02_AG and 1 that could not be classified. Most of these individuals were from other countries in Africa. Some of these sequences were in combination with subtype C, possibly indicating local recombination events. Although there is no indication of endemic spread of these viruses, continued monitoring is warranted to track genetic changes, which may impact on diagnostic testing, therapeutic responses to antiretroviral therapies, and vaccine design.

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