Review
doi: 10.1111/j.1749-6632.2002.tb04264.x.
Free fatty acid metabolism in human skeletal muscle is regulated by PPARgamma and RXR agonists
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- PMID: 12079836
- DOI: 10.1111/j.1749-6632.2002.tb04264.x
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Review
Free fatty acid metabolism in human skeletal muscle is regulated by PPARgamma and RXR agonists
Ann N Y Acad Sci.
2002 Jun.
Abstract
Free fatty acid (FFA) oxidation in human skeletal muscle cells can be stimulated, both independently and in a synergistic manner, by agonists for PPARgamma and RXR. Increased FFA disposal in muscle through augmented oxidation could reduce intramyocellular lipid accumulation. The abilities of such agents to improve glucose tolerance and insulin action may thus involve effects on both glucose and FFA metabolism.
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