[Clinical observation on ondansetron in preventing nausea and vomiting after cholecystectomy under abdominoscope]

Abstract

Objective: To evaluate the prophylactic effect of ondansetron on postoperative nausea and vomiting (PONV) of cholecystectomy under abdominoscope.

Methods: Sixty patients, scheduled for selective cholecystectomy under abdominoscope, were randomly and double-blindly allocated to receive an intravenous bolus of either 0.9% NS 10 ml(Group placebo, n = 30) or 8 mg of ondansetron in 10 ml solution(Group ondansetron, n = 30), respectively.

Results: The incidences of nausea and vomiting in ondansetron group(33.3% and 26.7%) were significantly lower than those in placebo group(73.3% and 66.7%) (P < 0.05). Administration of ondansetron had no obvious effect on the mean arterial pressure, SpO2, and respiratory frequency.

Conclusion: Ondansetron can be used effectively and safely to prevent PONV in cholecystectomy patients under abdominoscope.