["Subclinical" thyroid disease]

Abstract

Background: It is generally easy to diagnose and treat patients with thyroid diseases, though there has been considerable uncertainty over whether or not to treat patients with subclinical disease.

Material and methods: An overview of clinical symptoms and complications related to subclinical thyroid disease is presented on the basis of relevant literature.

Results: Patients with subclinical hypothyreosis (elevated TSH level and normal free T4) may benefit from treatment with thyroxine in relation to well-being, serum lipid levels, and possibly also blood pressure. Patients with subclinical hyperthyreosis (suppressed TSH level and normal free T4) have an increased risk of developing atrial fibrillation and possibly also dementia.

Interpretation: Subclinical thyroid disease is usually progressive. If a transient condition is ruled out, proper treatment should not be delayed.