Comparative Study
doi: 10.1016/s0006-291x(02)00618-6.
The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids
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- PMID: 12083758
- DOI: 10.1016/s0006-291x(02)00618-6
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Comparative Study
The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids
Biochem Biophys Res Commun.
.
Abstract
Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone. The potent activity of 2,6-dihydroxyacetophenone is due to stabilisation of its radical via tautomerisation. The antioxidant pharmacophore in the dihydrochalcone phloretin, i.e., the 2,6-dihydroxyacetophenone group, is different from the antioxidant pharmacophores previously reported in flavonoids.
(c) 2002 Elsevier Science (USA).
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