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Review
. 2002 Jul;57(7):B257-69.
doi: 10.1093/gerona/57.7.b257.

Replicative senescence revisited

Richard Marcotte  1 , Eugenia Wang
Affiliations
Review

Replicative senescence revisited

Richard Marcotte et al. J Gerontol A Biol Sci Med Sci. 2002 Jul.

Abstract

Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested state are being discovered at a great pace. This review discusses the latest findings on the players responsible for establishing replicative senescence, as well as the associated telomere shortening.

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