Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Jun 17;86(12):1909-13.
doi: 10.1038/sj.bjc.6600364.

Expression of cdc25A and cdc25B proteins in thyroid neoplasms

Y Ito  1 , H Yoshida, K Nakano, K Kobayashi, T Yokozawa, K Hirai, F Matsuzuka, N Matsuura, K Kakudo, K Kuma, A Miyauchi
Affiliations
Free PMC article

Expression of cdc25A and cdc25B proteins in thyroid neoplasms

Y Ito et al. Br J Cancer. .
Free PMC article

Abstract

Cdc25B and cdc25A phosphates are prominent stimulators of cell cycle progression and recent studies have also suggested their oncogenic roles. To elucidate the role of these proteins in thyroid neoplasms, we immunohistochemically investigated their expression, and neither protein was expressed in normal follicular cells. Cdc25B was frequently overexpressed in follicular adenoma and minimally invasive follicular carcinoma, but the incidence was significantly lower in widely invasive follicular carcinoma. Furthermore, the cdc25B expression level significantly decreased with the dedifferentiation of thyroid carcinoma. Cdc25A overexpression was observed in high incidences in all types of thyroid neoplasms. These results suggest that cdc25B and cdc25A play oncogenic roles in thyroid follicules and that cdc25B works predominantly in the early phase of the progression of thyroid carcinoma, whereas cdc25A plays a fundamental role in the development of thyroid neoplasms.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Immunostaining of cdc25B. (A) cdc25B overexpression in minimally invasive follicular carcinoma (+++). (B) cdc25B overexpression in widely invasive follicular carcinoma with solid growth pattern (++). (C) cdc25 overexpression in papillary carcinoma (+++). (D) cdc25 was negative in undifferentiated carcinoma (−).
Figure 2
Figure 2
Immunostaining of cdc25A. (A) cdc25A overexpression in cytoplasms of papillary carcinoma (+++). (B) cdc25A overexpression in cell nuclei of undifferentiated carcinoma (+++). (C) cdc25A overexpression in cytoplasms and cell nuclei of follicular adenoma (+++). Scale bars: 150 μm.
See this image and copyright information in PMC

References

    1. AldingerKASamaanNAIbanezMHillJrCS1978Anaplastic carcinoma of the thyroid: a review of 84 cases of spindle and giant-cell carcinoma of the thyroid Cancer 4122672275 - PubMed
    1. BrogginiMBuraggiGBrennaARivaLCodegoniAMTorriVLissoniAAMangioniCD'IncalciM2000Cell cycle-related phosphatases CDC25A and B expression correlates with survival in ovarian cancer patients Anticancer Res 2048354840 - PubMed
    1. DixonDMoyanaTKingMJ1998Elevated expression of the cdc25A protein phosphatase in colon cancer Exp Cell Res 240236243 - PubMed
    1. EricksonLAJinLWollanPCThompsonGBvan HeerdenJLloydRB1998Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors Mod Pathol 11169174 - PubMed
    1. FagginJA2000Molecular genetics of tumors of thyroid follicular cellsInThe Thyroid8th edBraverman LE, Utiger RD (eds)pp886898Lippincott Williams & Wilkins

MeSH terms