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. 2002 Jul 1;87(1):8-14.
doi: 10.1038/sj.bjc.6600335.

Outcome after extended follow-up in a prospective study of operable breast cancer: key factors and a prognostic index

R A Hawkins  1 , A L Tesdale, R J Prescott, T Forster, M A McIntyre, P Baker, W J L Jack, U Chetty, J M Dixon, M E Killen, M J Hulme, W R Miller
Affiliations

Outcome after extended follow-up in a prospective study of operable breast cancer: key factors and a prognostic index

R A Hawkins et al. Br J Cancer. .

Abstract

In 1990, 215 patients with operable breast cancer were entered into a prospective study of the prognostic significance of five biochemical markers and 15 other factors (pathological/chronological/patient). After a median follow-up of 6.6 years, there were 77 recurrences and 77 deaths (59 breast cancer-related). By univariate analysis, patient outcome related significantly to 13 factors. By multivariate analysis, the most important of nine independent factors were: number of nodes involved, steroid receptors (for oestrogen or progestogen), age, clinical or pathological tumour size and grade. Receptors and grade exerted their influence only in the first 3 years. Progestogen receptors (immunohistochemical) and oestrogen receptors (biochemical) were of similar prognostic significance. The two receptors were correlated (r=+0.50, P=0.001) and displaced each other from the analytical model but some evidence for the additivity of their prognostic values was seen when their levels were discordant.

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Figures

Figure 2
Figure 2
Kaplan–Meier curves for overall survival in 214 patients with operable breast cancer, after division of the patients into quartiles (for Path T size, these were <1.5, ⩾1.5–<2.2, ⩾2.2–3.0 and >3.0 cm; for ER <11, 11–63, 64–164 and >164 fmol mg−1 protein and for age, <49, ⩾49–⩽55, 56–63 and >63 years) or four groups (Nodes involved 0, 1, 2 and >3).
Figure 3
Figure 3
Comparison of the relationships between ER, determined by biochemistry, and PgR, determined by immunohistochemistry, to disease-free survival, using optimised levels.
Figure 1
Figure 1
The relationship between ER measured by biochemistry and PgR detected by immunohistochemical staining in 204 patients with operable breast cancer. Spearman's Rank correlation coefficient=+0.50, P<0.001.
Figure 4
Figure 4
The relationship between the percentage of patients surviving from breast cancer and (a) the Nottingham Prognostic Index (dotted line) and (b) a Steroid receptor-modified NP Index (solid line) for 177 patients with operable breast cancer. Percentage survival values are plotted at the mid-point for each range of indices, e.g. at 2.9 for the group ranging from 2.4–3.4.
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References

    1. AdamiHOMalkerBMeirikOPerssonIBerqvistStoneB1985Age as prognostic factor in breast cancer Cancer 56898902 - PubMed
    1. AndersonEDCForrestAPMLevackPAChettyUHawkinsRA1989Response to endocrine manipulation and oestrogen receptor concentration in large, operable, primary breast cancer Br J Cancer 60223226 - PMC - PubMed
    1. BakerPRWalkerRADunnJAParnellSMStonelakePSJevonsCMGillespieWMBakerPGDodsonLOatesGDEllisDJLeeMJRMorrisonJMSpoonerD1995Pathological and immunohistochemical prognostic factors in clinically node-negative breast cancer patients receiving adjuvant tamoxifen (BR 3002 Trial) The Breast 4237(abstract)
    1. BarrancoSCPerryRRDurmMEWernerALGegorcykSGBoltonWEKolmPTownsendCM1994Intratumor variability in prognostic indicators may be the cause of conflicting estimates of patient survival and response to therapy Cancer Res 5453515356 - PubMed
    1. BlameyRW1996The design and use of Nottingham Prognostic Index in breast cancer The Breast 5156157

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