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. 2002 Jul 1;87(1):28-30.
doi: 10.1038/sj.bjc.6600362.

Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

X Bu  1 , L Bernstein, R K Brynes
Affiliations

Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

X Bu et al. Br J Cancer. .

Abstract

Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.

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