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. 2002 Jul 1;87(1):28-30.
doi: 10.1038/sj.bjc.6600362.

Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

X Bu  1 , L Bernstein, R K Brynes
Affiliations

Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

X Bu et al. Br J Cancer. .

Abstract

Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.

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References

    1. CarrelLCottleAAGoglinKCWillardHF1999A first-generation X-inactivation profile of the human X chromosome Proc Natl Acad Sci 961444014444 - PMC - PubMed
    1. CrewAJClarkJFisherCGillSGrimerRChandAShipleyJGustersonBACooperCS1995Fusion of SYT to two genes. SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma EMBO J 1423332340 - PMC - PubMed
    1. dos SantosNRde BruijmDRHvan KesselAG2001Molecular mechanisms underlying human synovial sarcoma development Genes Chromosomes Cancer 30114 - PubMed
    1. FligmanILongardoFJhanwarSCGeraldWLWoodruffJLadanviM1995Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript Am J Pathol 14715921599 - PMC - PubMed
    1. International Human Genome Sequencing Consortium2001Initial sequencing and analysis of the human genome Nature 409860921 - PubMed

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