Review
doi: 10.1034/j.1600-065x.2001.1840102.x.
Thymic development and repertoire selection: the rat perspective
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- PMID: 12086323
- DOI: 10.1034/j.1600-065x.2001.1840102.x
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Review
Thymic development and repertoire selection: the rat perspective
Immunol Rev.
2001 Dec.
Abstract
This review summarizes our current knowledge of T-cell maturation and repertoire selection in the rat thymus. Some unique features of early thymocyte development and of CD4/CD8 lineage decision are described. A detailed analysis of lineage progression through the CD4, CD8 "double positive" compartment and T-cell receptor-induced CD8 T-cell maturation in cell culture is provided. A second emphasis is placed on interactions between germline-encoded T-cell receptor elements with MHC molecules in thymic repertoire selection and alloreactivity
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