doi: 10.1016/s1097-2765(02)00554-3.
A mark in the core: silence no more!
Affiliations
- PMID: 12086611
- DOI: 10.1016/s1097-2765(02)00554-3
Item in Clipboard
A mark in the core: silence no more!
Mol Cell.
2002 Jun.
Free article
Abstract
The histone modification repertoire has recently been expanded. Dot1p is a new type of methyltransferase that methylates lysine 79 in the histone H3 core only in its nucleosomal context and has a possible role in marking open chromatin regions.
Similar articles
-
Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast.Nat Commun. 2018 Jan 16;9(1):240. doi: 10.1038/s41467-017-02759-8. Nat Commun. 2018. PMID: 29339748 Free PMC article.
-
Dot1p modulates silencing in yeast by methylation of the nucleosome core.Cell. 2002 Jun 14;109(6):745-56. doi: 10.1016/s0092-8674(02)00759-6. Cell. 2002. PMID: 12086673
-
A lysine-rich region in Dot1p is crucial for direct interaction with H2B ubiquitylation and high level methylation of H3K79.Biochem Biophys Res Commun. 2010 Sep 3;399(4):512-7. doi: 10.1016/j.bbrc.2010.07.100. Epub 2010 Aug 3. Biochem Biophys Res Commun. 2010. PMID: 20678485
-
Cross-talking histones: implications for the regulation of gene expression and DNA repair.Biochem Cell Biol. 2005 Aug;83(4):460-7. doi: 10.1139/o05-116. Biochem Cell Biol. 2005. PMID: 16094449 Review.
-
Histone lysine methylation and chromatin replication.Biochim Biophys Acta. 2014 Dec;1839(12):1433-9. doi: 10.1016/j.bbagrm.2014.03.009. Epub 2014 Mar 28. Biochim Biophys Acta. 2014. PMID: 24686120 Review.
Cited by
-
Modifications of histone cores and tails in V(D)J recombination.Genome Biol. 2003;4(4):211. doi: 10.1186/gb-2003-4-4-211. Epub 2003 Mar 31. Genome Biol. 2003. PMID: 12702201 Free PMC article. Review.
-
The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components.Mol Cell Proteomics. 2013 Mar;12(3):764-80. doi: 10.1074/mcp.M112.024307. Epub 2013 Jan 14. Mol Cell Proteomics. 2013. PMID: 23319141 Free PMC article.
-
Spatial distribution of histone methylation during MHC class II expression.Mol Immunol. 2008 Feb;45(4):971-80. doi: 10.1016/j.molimm.2007.07.039. Epub 2007 Sep 11. Mol Immunol. 2008. PMID: 17850872 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
