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. 2002 Apr;1(3):237-46.
doi: 10.1016/s1535-6108(02)00043-0.

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Keiichi Kondo  1 , Jeff Klco, Eijiro Nakamura, Mirna Lechpammer, William G Kaelin Jr
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Free article

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Keiichi Kondo et al. Cancer Cell. 2002 Apr.
Free article

Abstract

Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The VHL gene product, pVHL, targets the heterodimeric transcription factor HIF for polyubiquitination, and restoration of pVHL function in VHL(-/-) renal carcinoma cells suppresses their ability to form tumors in nude mice. Here we show that tumor suppression by pVHL can be overridden by a HIF variant that escapes pVHL control. These studies prove that HIF is a critical downstream target of pVHL and establish that activation of HIF target genes can promote tumorigenesis in vivo.

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  • Two HIFs may be better than one.
    Seagroves T, Johnson RS. Seagroves T, et al. Cancer Cell. 2002 Apr;1(3):211-3. doi: 10.1016/s1535-6108(02)00048-x. Cancer Cell. 2002. PMID: 12086854

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