Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Jul;51(7):1997-2004.
doi: 10.2337/diabetes.51.7.1997.

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research

L Marie Scearce  1 , John E Brestelli, Shannon K McWeeney, Catherine S Lee, Joan Mazzarelli, Deborah F Pinney, Angel Pizarro, Christian J Stoeckert Jr, Sandra W Clifton, M Alan Permutt, Juliana Brown, Douglas A Melton, Klaus H Kaestner
Affiliations

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research

L Marie Scearce et al. Diabetes. 2002 Jul.

Abstract

Over the past 5 years, microarrays have greatly facilitated large-scale analysis of gene expression levels. Although these arrays were not specifically geared to represent tissues and pathways known to be affected by diabetes, they have been used in both type 1 and type 2 diabetes research. To prepare a tool that is particularly useful in the study of type 1 diabetes, we have assembled a nonredundant set of 3,400 clones representing genes expressed in the mouse pancreas or pathways known to be affected by diabetes. We have demonstrated the usefulness of this clone set by preparing a cDNA glass microarray, the PancChip, and using it to analyze pancreatic gene expression from embryonic day 14.5 through adulthood in mice. The clone set and corresponding array are useful resources for diabetes research.

PubMed Disclaimer

Publication types