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Case Reports
. 1975 Nov 21;44(3):273-80.
doi: 10.1007/BF00428906.

Clinical studies with dopamine-receptor stimulants

B Angrist, H Thompson, B Shopsin, S Gershon
Case Reports

Clinical studies with dopamine-receptor stimulants

B Angrist et al. Psychopharmacologia. .

Abstract

Oral administration of ET-495 was found to cause worsening of psychiatric status in 4 out of 7 schizophrenic patients, and to induce a paranoid state and a syndrome of auditory hallucinosis in 2 non-schizophrenics. These observations were compatible with the hypothesized role of dopamine in schizophrenia. However, these psychotogenic effects were far less dramatic than those noted in other studies with amphetamine, methylphenidate or L-Dopa. Possible explanations for this differing psychotogenic potency of receptor stimulators versus presynaptic agonists are presented. Intravenous ET-495 and apomorphine did not show psychotogenic effects.

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