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Review
. 2002 Jun;31(2):369-89, vii.
doi: 10.1016/s0889-8529(01)00010-x.

Autoantibodies in autoimmune polyendocrine syndrome type II

Alberto Falorni  1 , Stefano Laureti, Fausto Santeusanio
Affiliations
Review

Autoantibodies in autoimmune polyendocrine syndrome type II

Alberto Falorni et al. Endocrinol Metab Clin North Am. 2002 Jun.

Abstract

The autoimmune polyendocrine syndrome type II (APS-II) is characterized by the association of autoimmune Addison's disease with thyroid autoimmune diseases or type-1 diabetes mellitus. 21-Hydroxylase autoantibodies enable the accurate diagnosis of autoimmune Addison's disease and, in patients with other endocrine autoimmune diseases, identify subjects at high risk for clinical adrenal insufficiency. 17 alpha-Hydroxylase (17OH) and side-chain-cleavage enzyme (P450scc) are target autoantigens of steroid-cell autoantibodies, and in women with Addison's disease, 17OH autoantibodies and P450scc autoantibodies are markers of increased risk for premature ovarian failure. Thyroperoxidase autoantibodies, thyroglobulin autoantibodies, H+/K(+)-ATPase autoantibodies, and GAD65 autoantibodies are frequently detected in patients with isolated Addison's or APS-II. Screening for other organ-specific autoimmune diseases should be performed in every patient with at least one major disease component of APS-II.

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