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. 2002 May;66(5):1093-6.
doi: 10.1271/bbb.66.1093.

Short-step syntheses of all stereoisomers of preussin and their bioactivities

Masayuki Okue  1 , Hidenori Watanabe, Koji Kasahara, Minoru Yoshida, Sueharu Horinouchi, Takeshi Kitahara
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Free article

Short-step syntheses of all stereoisomers of preussin and their bioactivities

Masayuki Okue et al. Biosci Biotechnol Biochem. 2002 May.
Free article

Abstract

All the eight stereoisomers of (+)-preussin (1b), an antifungal agent inhibiting the growth of fission yeast and human cancer cells, were synthesized in two steps by non-stereoselective reactions and chromatographic separation, starting from L- and D-N-protected-phenylalaninal (2). Their bioassay revealed all of the stereoisomers to be almost equally bioactive.

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