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Comparative Study
. 1979 Dec;4(6):703-12.
doi: 10.1007/BF00964467.

Properties of [3H]taurine release from crude synaptosomal fractions of rat cerebral cortex

P Placheta, E Singer, W Sieghart, M Karobath
Comparative Study

Properties of [3H]taurine release from crude synaptosomal fractions of rat cerebral cortex

P Placheta et al. Neurochem Res. 1979 Dec.

Abstract

The release of previously accumulated [3H]taurine and [14C]GABA from crude synaptosomal (P2) fractions isolated from rat cerebral cortex was studied using a superfusion system. The spontaneous efflux of [3H]taurine and [14C]GABA was stimulated by elevated concentrations of K+ (15--133 mM) in a concentration-dependent manner. This K+-stimulated relase of [14C]Gaba but not of [3H]taurine was enhanced in the presence of Ca2+. However, addition of 3 mM Ca2+ to the superfusion medium in the presence of the ionophore A 23187 resulted in a stimulation of the release of both [3H]taurine and [14C]GABA. These results are discussed in connection with the cellular localization of taurine in the central nervous system.

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