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Review
. 2002 Jul 9;99(14):9084-6.
doi: 10.1073/pnas.152280699. Epub 2002 Jul 1.

The COXes of Danio: from mechanistic model to experimental therapeutics

Stephen M Prescott  1 , H Joseph Yost
Affiliations
Review

The COXes of Danio: from mechanistic model to experimental therapeutics

Stephen M Prescott et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Pathway for prostaglandin synthesis. Arachidonic acid is found in membrane phospholipids in resting cells and is released as a free fatty acid by the action of phospholipase(s). It then can be a substrate for a variety of enzymes that catalyze the addition of oxygen, resulting in multiple products with diverse physiological actions. The free arachidonic acid itself has a variety of effects on intracellular signaling and can be recycled back to phospholipids. Cyclooxygenases –1 and –2 are the targets for NSAIDs and the specific COX-2 inhibitors.
Figure 2
Figure 2
Prostaglandins can signal by means of multiple mechanisms. Prostaglandins usually are secreted and then bind to G protein-coupled receptors on the target cells. In most cases, it is thought that the target is either the synthesizing cell itself (autocrine signaling) or a neighboring cell (paracrine). In some cases, particularly with pharmacological use of prostaglandins, they circulate in the blood to effect a signal in remote cells (endocrine). Lastly, prostaglandins can bind to nuclear transcription factors to induce gene expression, and this can occur within the same cell (intracrine).
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Comment on

References

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