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Review
. 2002 Jul;3(7):531-7.
doi: 10.1038/nrm859.

Opinion: Building epithelial architecture: insights from three-dimensional culture models

Lucy Erin O'Brien  1 , Mirjam M P Zegers, Keith E Mostov
Affiliations
Review

Opinion: Building epithelial architecture: insights from three-dimensional culture models

Lucy Erin O'Brien et al. Nat Rev Mol Cell Biol. 2002 Jul.

Abstract

How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.

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