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. 2002 Jul;8(7):697-701.
doi: 10.3201/eid0807.010427.

Temporal changes in prevalence of antimicrobial resistance in 23 US hospitals

Scott K Fridkin  1 , Holly A Hill, Nataliya V Volkova, Jonathan R Edwards, Rachel M Lawton, Robert P Gaynes, John E McGowan Jr; Intensive Care Antimicrobial Resistance Epidemiology Project Hospitals
Affiliations

Temporal changes in prevalence of antimicrobial resistance in 23 US hospitals

Scott K Fridkin et al. Emerg Infect Dis. 2002 Jul.

Abstract

Antimicrobial resistance is increasing in nearly all health-care-associated pathogens. We examined changes in resistance prevalence during 1996-1999 in 23 hospitals by using two statistical methods. When the traditional chi-square test of pooled mean resistance prevalence was used, most organisms appear to have increased in prevalence. However, when a more conservative test that accounts for changes within individual hospitals was used, significant increases in prevalence of resistance were consistently observed only for oxacillin-resistant Staphylococcus aureus, ciprofloxacin-resistant Pseudomonas aeruginosa, and ciprofloxacin- or ofloxacin-resistant Escherichia coli. These increases were significant only in isolates from patients outside intensive-care units (ICU). The increases seen are of concern; differences in factors present outside ICUs, such as excessive quinolone use or inadequate infection-control practices, may explain the observed trends.

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References

    1. McGowan JE Jr, Tenover FC. Control of antimicrobial resistance in the health care system. Infect Dis Clin North Am. 1997;11:297–311. 10.1016/S0891-5520(05)70357-3 - DOI - PubMed
    1. Schwartz B, Bell D, Hughes JM. Preventing the emergence of antimicrobial resistance: a call for action by clinicians, public health officials, and patients. JAMA. 1997;278:944–5. 10.1001/jama.278.11.944 - DOI - PubMed
    1. Deikema DJ, Pfaller MA, Schmitz FJ, Smayevsky J, Bell J, Jones RN, et al. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis. 2001;32:S114–32. 10.1086/320184 - DOI - PubMed
    1. Gales AC, Jones RN, Turnidge J, Rennie R, Ramphal R. Characterization of Pseudomonas aeruginosa isolates: occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the Global SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis. 2001;32:S146–55. 10.1086/320186 - DOI - PubMed
    1. Low DE, Keller N, Barth A, Jones RN. Clinical prevalence, antimicrobial susceptibility, and geographic resistance patterns of enterococci: results from the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis. 2001;32:S133–45. 10.1086/320185 - DOI - PubMed

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