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. 2002 Jul 4;418(6893):38-9.
doi: 10.1038/418038a.

RNA interference in adult mice

Anton P McCaffrey  1 , Leonard Meuse, Thu-Thao T Pham, Douglas S Conklin, Gregory J Hannon, Mark A Kay
Affiliations

RNA interference in adult mice

Anton P McCaffrey et al. Nature. .

Abstract

RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.

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