Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Dec 30;3(4):165-7.
doi: 10.1007/BF00261952.

Concentration of antibiotics in renal interstitial fluid: an experimental model

H U Eickenberg, N G Waterman, L Scharfenberger

Concentration of antibiotics in renal interstitial fluid: an experimental model

H U Eickenberg et al. Urol Res. .

Abstract

In a new canine experimental model the time concentration relationship of cephalothin in serum, urine, soft tissue interstitial fluid (STIF) and renal interstitial fluid (RIF) were compared simultaneously. Antibiotic concentration in RIF was less than urinary levels but exceeded the serum concentration. Urinary antibiotic concentration does not necessarily reflect concentration in the renal interstitium. This model helps to understand the basic pharmacokinetics of antibiotics in the renal interstitium where pyelonephritis occurs.

PubMed Disclaimer

References

    1. Arch Surg. 1972 Aug;105(2):192-6 - PubMed
    1. Physiol Rev. 1971 Jul;51(3):527-63 - PubMed
    1. Br Med J. 1973 Mar 10;1(5853):569-73 - PubMed
    1. Medicine (Baltimore). 1965 Jan;44:1-36 - PubMed
    1. N Engl J Med. 1965 May 20;272:0137-44 - PubMed