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. 2002 Jul 11;4(14):2417-20.
doi: 10.1021/ol020097p.

The first successful base-promoted isomerization of propargyl amides to chiral ynamides. Applications in ring-closing metathesis of ene-ynamides and tandem RCM of diene-ynamides

Jian Huang  1 , Hui Xiong, Richard P Hsung, C Rameshkumar, Jason A Mulder, Tyler P Grebe
Affiliations

The first successful base-promoted isomerization of propargyl amides to chiral ynamides. Applications in ring-closing metathesis of ene-ynamides and tandem RCM of diene-ynamides

Jian Huang et al. Org Lett. .

Abstract

[reaction: see text] A highly useful sequence of reactions is described here. These reactions consist of the first successful base-induced isomerizations of propargyl amides to chiral ynamides, applications of these novel ynamides in ring-closure metathesis leading to chiral 2-amidodienes useful for Diels-Alder cycloadditions, and the first successful tandem RCM of diene-ynamides.

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