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. 2002 Jul 12;67(14):4975-7.
doi: 10.1021/jo020281o.

(P(C(6)H(5))(3))CpRu(+)-catalyzed deprotection of allyl carboxylic esters

Masato Kitamura  1 , Shinji Tanaka, Masahiro Yoshimura
Affiliations

(P(C(6)H(5))(3))CpRu(+)-catalyzed deprotection of allyl carboxylic esters

Masato Kitamura et al. J Org Chem. .

Abstract

A new and efficient catalytic method for deprotection of allyl carboxylic esters using a transition metal complex is reported. The reaction proceeds with a high substrate/catalyst ratio and without use of additional nucleophiles, giving the deprotected carboxylic acid in a quantitative yield. A variety of substrates, including the multifunctional amino acids and peptides, are also usable. The new method is more efficient, safe, and operationally simple in comparison to the conventional palladium-catalyzed method.

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