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Review
. 2001 Nov;1(4):307-12.

Cytomegalovirus (CMV) resistance to antivirals

W L Drew  1 , C V Paya, V Emery
Affiliations
  • PMID: 12099372
Free article
Review

Cytomegalovirus (CMV) resistance to antivirals

W L Drew et al. Am J Transplant. 2001 Nov.
Free article

Abstract

This article reviews the biology of cytomegalovirus (CMV), the approved antiviral therapies, and mechanisms of resistance to these drugs. The rates of resistance development in clinical trials are presented, as are the assays for testing susceptibility by phenotypic and genotypic methods. Factors that favor the development of clinical and in vitro antiviral resistance are discussed. Finally, approaches to altering antiviral therapy as resistance develops are outlined.

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